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Enzyme cost minimization Enzyme cost plays a major role in the
choice of metabolic routes, both in evolution and
bioengineering. Given desired fluxes, necessary enzyme
levels can be estimated based on known rate laws and on a
principle of minimal enzyme cost. This estimation is
greatly facilitated by formulating it as a convex
optimality problem. The set of feasible metabolite
profiles forms a polytope in log-concentration space,
whose points represent all possible steady states of a
kinetic model. |
On this website, you can software for enzyme cost minimization (in matlab and python), as well as all data files for an example, a kinetic model of central carbon metabolism in E. coli.
If you use enzyme cost minimization in your work, please cite our article
Noor E., Flamholz A., Bar-Even A., Davidi D., Milo R., Liebermeister W. (2016),
The protein cost of metabolic fluxes: prediction from enzymatic rate laws and cost minimization
PLoS Comp. Biol. 12 (10): e1005167